Professor Christopher Uff PhD, FRCS Consultant Neurosurgeon
Arterio-Venous Malformations (AVMs)
AVMs are abnormal collections of blood vessels in the brain that contain a direct connection between the arteries (that take blood away from the heart at high pressure) and veins (that take blood back to the heart at low pressure).
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They are usually congenital and are frequently asymptomatic.
They may bleed (causing intracerebral haemorrhage) or cause epilepsy.
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The main indication for treatment is previous bleeding or rarely intractible epilepsy.
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The bleeding risk is thought to be 1-2% per year if the AVM has not bled and double this once it has bled however the bleeding risk in the first year is
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Treatment must be considered on an individual basis and involves discussion between neurosurgeons, neuroradiologists, neurologists and radiosurgeons.
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Management may involve:
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Observation (conservative management)
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Endovascular embolization
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Microsurgical excision
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Gamma Knife Radiosurgery
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or any combination of the above.
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Cavernoma or Cavernous Malformation
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Cavernomas are pockets of abnormal blood vessels that may occur in the brain or the spinal cord.
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They are frequently asymptomatic but they may bleed and cause neurological problems.
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If they are in the top part of the brain (the cerebrum), they may also cause epileptic seizures.
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There is no medical treatment available other than controling seizures.
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Indications for surgery are cavernomas that have bled and cavernomas that are causing intractible epilepsy.


